Hyperplasia Breast Cancer Risk Information

Women diagnosed with breast atypical and non-atypical hyperplasias have an increased risk for breast cancer.

Breast Cancer is the most diagnosed cancer for women in the USA. One in eight women develops breast cancer in her life time. Every year approximately 800,000 to one Million U.S. women undergo a breast biopsy for a suspected tumor of which ~200,000 to 230,000 are cancerous and the rest are non-cancerous. Of the non-cancerous tumors, women diagnosed with Atypical Hyperplasias (lobular and ductal types), Usual Ductal Hyperplasias (UDH), Papilloma and Sclerosing Adenosis types of tumors have an increased risk of developing breast cancer.

One in five women diagnosed with atypias develops breast cancer within 5 or more years

Women who are diagnosed with either atypical ductal hyperplasias or atypical lobular hyperplasias are five times more likely to develop cancer than women who do not have these types of abnormal growths. Overall, about one in five women develops breast cancer within five or more years (References 1-17) after atypical diagnosis. The question has been how to identify those 20% of women who will go on to develop cancer from the 80% of those who will not develop cancer.

One in ten women diagnosed with non-atypical hyperplasias develops breast cancer within 5 or more years

Women diagnosed with tumors that have Usual Ductal Hyperplasias, Sclerosing Adenosis, Papilloma or a combination of any of these types have a two-fold increased risk of subsequently developing breast cancer. Overall about one in ten women develops breast cancer within five or more years (References 1-17) (Figure below) after diagnosis of these abnormal growths. Until now, there have not been any tests to identify the 10% of women who will go on to develop breast cancer.


Hyperplasia breast cancer risk

Different benign tumors have different risk levels. Usual hyperplastic tumors have a two-fold increased risk and atypical tumors have a five-fold increased risk of subsequent breast cancer development

Hyperplasia Breast Cancer Risk Testing

A New Genomic BBDRisk Dx™ Test is now available to assess risk

Silbiotech, Inc for the first time offers a new genomic test, BBDRisk Dx™, for women diagnosed with atypical or usual hyperplasias, sclerosing adenosis, papillomas or a combination of any of these types of abnormalities, to assess the level of risk for developing breast cancer. The test assays a unique set of cancer marker proteins in the tumor tissue and predicts the likelihood of developing breast cancer in the next five years after diagnosis (Figure below).

 

Hyperplasia breast cancer risk image

 

REFERENCES

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